(CNN) -- Diego Maradona's Argentina side have suffered their worst-ever World Cup defeat -- and heaviest loss in over 60 years -- going down 6-1 to Bolivia at La Paz's high-altitude Hernando Siles' stadium.
Bolivia players celebrate another goal as they humiliated Argentina 6-1 in La Paz.
Marcelo Martins opened the scoring for the hosts in the 12th minute but Argentina levelled 13 minutes later when a long-range shot from Luiz Gonzalez bounced in after deceiving goalkeeper Carlos Arias.
Joaquin Botero, who helped himself to a hat-trick, netted his first in the 34th minute from the penalty spot and Alex Da Rosa added a third just before the interval.
Botero headed home the fourth five minutes into the second-half, before Argentina's night got even worse when they had substitute Angel Di Maria sent off.
Botero celebrated his treble soon after Di Maria's dismissal and Didi Torrico completed the rout from long range with three minutes remaining.
The last time Argentina have lost by a five-goal margin was 5-0 to Colombia in 1993 and the home media made their feelings about the result perfectly clear.
"A historic humiliation," said sports newspaper Ole on its Web site, adding: "This is our worst defeat in the qualifiers. What now.?"
The result leaves Argentina in the fourth and final South American World Cup qualification place, five points behind leaders Paraguay, who scored an injury-time equalizer to draw 1-1 in Ecuador.
Meanwhile, Brazil are up to second in the table, two points behind Paraguay, after a comfortable 3-0 home victory over Peru at Porto Alegre. Luis Fabiano scored twice with Felipe Melo adding the other goal.
Chile are third in the table after a 0-0 home draw with Uruguay, who lie in the play-off fifth position.