(CNN) -- Andy Murray produced a sluggish performance as he was knocked out of the Paris Masters by Radek Stepanek on Thursday.
The 22-year-old Briton was beaten 1-6, 6-3, 6-4 in his third-round tie with the experienced 30-year-old from the Czech Republic.
Murray's exertions of the previous round against American James Blake -- which did not finish until 1:45 am on Thursday morning -- had clearly caught up with him although the opening exchanges went the way of the Scot.
Murray coasted the first set against the 13th seed but it was a different story in the second as tiredness and frustration began to creep into the fourth seed's game and Stepanek clinched it 6-3.
Stepanek began to pile on the pressure and when the Czech was able to capitalize on an earlier break to go 5-2 up in the seventh game before holding off a Murray fightback to win the deciding set 6-4.
The victory earns Stepanek a quarterfinal clash with either U.S. Open champion Juan Martin del Potro of Argentina or Fernando Gonzalez of Chile while Murray will turn his attentions to the ATP World Tour Finals taking place in London later this month.
Elsewhere, Sweden's Robin Soderling defeated Russian Nikolay Davydenko 6-3, 3-6, 6-4 while France's Jo-Wilfried Tsonga overcame compatriot Gilles Simon in straight sets with an emphatic 6-2, 6-3 victory.
Third seed Novak Djokovic of Serbia knocked out home favorite Arnaud Clement with ease 6-2, 6-2 while Marin Cilic bounced back from losing the first set to Fernando Verdasco to clinch a 3-6, 6-3 win.
Spain's Rafael Nadal and France's Gael Monfils also secured their places in the last eight with victories over fellow countrymen Tommy Robredo and Julian Benneteau respectively.