(CNN) -- The top two seeds, Dinara Safina and Venus Williams, have both been sent crashing in the second round of the Pan Pacific tournament in Tokyo on Monday.
Defending champion Safina suffered a shock defeat in the second round of the Pan Pacific Open.
World number one Dinara Safina was sent packing 7-6 4-6 7-5 by teenage qualifier Chang Kai-Chen, ranked 132nd in the world.
Meanwhile, Williams suffered a surprise 7-6 7-5 defeat at the hands of Safina's Russian compatriot Anastasia Pavlyuchenkova.
And there was a third shock when yet another Russian, French Open champion and fifth seed Svetlana Kuznetsova lost 7-5 4-6 6-3 to Germany's Andrea Petkovic.
Safina beat Kuznetsova in last year's final and Monday's matches were their first in the tournament as the top eight seeds all received first round byes.
"It is disappointing that I didn't play the way I should play in the match. Although I still turned the match around, I had lots of chances in the third set but I just let it go," Safina told reporters, after her marathon two hour, 44 minute defeat.
"I think she played great tennis, I just didn't do my tennis on court. She was always on the ball, she was always in her comfort zone. I never threw her out of her comfort zone so it was my fault."
Maria Sharapova, the 2005 champion, went close to making it three top Russian eliminated, but she recovered from losing the opening set to beat Francesca Schiavone of Italy 4-6 7-5 6-1.
In other first-round action, 14th seed Marion Bartoli of France crushed Romanian Sorana Cirstea 6-3 6-0, while Australian Samantha Stosur of Australia beat American Alexa Glatch 7-5 6-0.
China's Zheng Jie defeated India's Sania Mirza 5-7 6-2 6-3, while 16th seed Virginie Razzano of France was beaten in three sets by Czech Iveta Benesova.