(CNN) -- French Open champion Ana Ivanovic has followed Serena Williams in exiting the Rome Masters, after the Serb was beaten by Poland's Agnieszka Radwanska in three sets on Wednesday.
French Open champion Ivanovic goes into this year's event without a 2009 WTA Tour title.
Fifth seed Ivanovic squandered a 4-0 lead in the third set, as 10th seed Radwanska reeled off six games in a row to reach the quarterfinals with a 6-1 3-6 6-4 victory.
Ivanovic, who has struggled with injury and form since her success at Roland Garros last June, has not won a tournament this year and has reached only one final.
Her defeat follows Serena Williams' early exit from the competition. The American second seed was still on court well past midnight and, on her least favorite clay-court surface, was sent packing 6-2 2-6 6-1 by Swiss Patty Schnyder.
Meanwhile reigning two-time champion Jelena Jankovic barely had to break sweat as she coasted into the last eight when Kateryna Bondarenko retired with an illness.
Their third round match had been uncompetitive before the Ukrainian's retirement with third seed Jankovic charging to a 6-1 1-0 lead before the end came.
Third seed Jankovic will play seventh seed Svetlana Kuznetsova next after the Russian defeated home hope and 12th seed Flavia Pennetta 6-3 3-6 6-0.
Also through is sixth seed Victoria Azarenka of Belarus, who looked in impressive form as she thrashed ninth-seeded Dane Caroline Wozniacki 6-2 6-2.
Meanwhile, former champion and local favorite Philipp Kohlschreiber is out of the BMW Open in Munich after going out in straight sets to second seed Marin Cilic.
The 25-year-old Kohlschreiber won his maiden ATP title here two years ago, but he could not repeat that form against the Croatian, going down 6-0 6-4.
Cilic, ranked 15th in the world, will next play France's Jeremy Chardy, who beat another German Nicolas Kiefer 6-4 7-6, in Friday's quarterfinals.
Earlier, third seed Nicolas Almagro made a shock exit when he was beaten in straight sets by Russia's Mikhail Youzhny in their second round match.