(CNN) -- Sixth seed Svetlana Kuznetsova has failed in her attempts to reach a third successive Indian Wells final, crashing out in three sets to Polish wildcard Urszula Radwanska.
Russian Kuznetsova will not be reaching the Indian Wells final again this year.
Russian Kuznetsova was beaten 6-2 4-6 6-3 by Radwanska, ranked 107th in the world, who prevailed despite being troubled throughout the match by an ankle injury.
The defeat ended Kuznetsova's hopes of improving on her two runner-up finishes at this combined ATP Masters series and WTA tournament over the past two years. In 2007 she lost to Daniela Hantuchova and last year to Serbian Ana Ivanovic.
Top seed Dinara Safina made it safely through to the third round after beating Bulgarian Tsvetana Pironkova 7-6 6-2 and will next face 28th seed Peng Shuai of China, who saw off Olga Govortsova of Belarus 6-3 3-6 6-4.
With world number one Serena Williams not playing in California, the 22-year-old Russian can top the world rankings with victory here.
Fourth seed Vera Zvonareva is athrough after a 6-2 6-2 victory over Chan Yung-Jan of Taiwan, while there were also wins for eighth seed Victoria Azarenka of Belarus and ninth-seeded Dane Caroline Wozniacki.
Second seed Jelena Jankovic, fellow-Serb Ivanovic and third-seeded Russian Elena Dementieva all begin the tournament on Sunday.
The men's seeds also begin on Saturday, with world number two and second seed Roger Federer taking on France's Marc Gicquel, while fourth-seeded Briton Andy Murray faces Albert Montanes.
World number one Rafael Nadal of Spain and third-seeded Serb Novak Djokovic -- the defending champion -- will launch their bids on Sunday.