(CNN) -- Germany goalkeeper Robert Enke is out of Saturday's World Cup qualifier against Russia and next Wednesday's match against Wales after breaking his hand in training.
Enke is likely to be out of action for several weeks after breaking a bone in his hand during training.
The 31-year-old, who succeeded Jens Lehmann as his country's first-choice goalkeeper after Euro 2008, broke the scaphoid bone in his hand on Wednesday afternoon and the injury was confirmed on Thursday.
The Hanover shot-stopper will be out for several weeks and will miss Saturday's Group Four game in Dortmund against Russia as well as the match with Wales in Moenchegladbach next week.
"I knew immediately it was something bad," said Enke. "I just have to concentrate on getting back to fitness as soon as possible."
It means either Werder Bremen's Tim Wiese or Bayer Leverkusen's Rene Adler will make their international debut on Saturday.
Adler, 23, looks most likely to replace Enke after Germany manager Oliver Bierhoff hinted at the Leverkusen player's inclusion.
"I am really sorry for Robert," said Adler. "We get on well as friends and injuries are a hard thing for any footballer to accept, but injuries and suspensions are part and parcel of football, you have to take your chances when they come.
A 6-0 win over Liechtenstein and a 3-3 draw with Finland last month means Germany are top of Group Four with four points from second-placed Russia, who have three points but have a game in hand.