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Gene mutation protects against milk shakes and other fatty fare

  • Story Highlights
  • Study: Gene mutation protects against jump in cholesterol after high-fat fare
  • After milkshake, mutation carriers had lower triglycerides and LDL than others
  • Researchers say APOC3 mutation is relatively rare
  • Mutation discovery may help researchers develop new heart-disease therapies
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By Patrick Sauer
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Health

Some people have all the luck. A new study shows that certain individuals with a gene mutation can slurp down milk shakes or other high-fat food and drink without a nasty jump in cholesterol.

The APOC3 mutation seems to protect the heart by speeding up the breakdown of triglycerides, a type of fat.

It's almost like being born with a built-in cholesterol-lowering drug. The gene is called APOC3, and researchers found that 5 percent of the people they studied -- who were all Amish, in this case -- had the protective mutation, according to the report in Science.

The researchers haven't tested a lot of people so far, but they think the gene mutation is relatively rare. (The Amish, who tend to be genetically similar because of their social segregation, sometimes have much higher or much lower levels of certain mutations than those found in the general population.)

They do know that it seems to work by speeding up the breakdown of triglycerides, a type of fat. In the study, Toni Pollin Ph.D., an assistant professor of medicine at the University of Maryland School of Medicine, in Baltimore, and colleagues gave 809 members of the Old Order Amish community in Lancaster County, Pennsylvania, a super-high-fat milk shake (78 percent of calories from fat), and then tracked them for the next six hours.

They monitored how volunteers' arteries coped with the fatty drink and checked for calcium deposits in their coronary arteries, a sign of heart disease. Health.com: Nine surprising heart attack risks

The researchers tested the participants' DNA and found that those who coped with the fatty drink better than others had an APOC3 mutation. The mutation carriers had less artery calcification, indicating that they had healthier hearts as well as higher HDL (good cholesterol), and lower triglycerides and LDL (bad cholesterol). Health.com: What puts you at risk for high cholesterol?

If you're not one of the lucky gene carriers, it's still good news. The gene mutation ends up causing lower-than-normal production of a protein called ApoCIII. You may have heard of some of the other factors that indirectly lower ApoCIII: weight loss, cholesterol-lowering drugs, and fish oil.

The discovery that directly lowering ApoCIII via the mutation is not harmful -- and indeed, might be beneficial -- could help researchers develop new therapies to fight heart disease, says Pollin. Health.com: 10 best foods for your heart

Pollin adds that the gene variant is rare in the general population, but the effects of reducing the amount of ApoCIII can be universally beneficial. "Over a lifetime, having less ApoCIII confers a favorable lipid profile, which appears to be cardio-protective," Pollin says.

Karol Watson, M.D., Ph.D., codirector of preventative cardiology at the University of California, Los Angeles, cautions that although some cholesterol-lowering drugs decrease ApoCIII, it is an indirect effect and not the primary reason they protect against cardiovascular disease. She did say that the new study and others like it could have important implications for fighting heart disease in the general population. Health.com: From superfoods to calorie legislation, the top 10 food stories of 2008

"In the last few years, a couple of different genetic mutations have been discovered that confer lifelong beneficial positive lipid levels and protection from heart disease," she says. "It's a great starting point for possible drug development or public health measures. Hopefully, understanding and researching this small Amish group will help us find broader approaches that can do the same thing for us genetically unlucky people."

The study, part of the University of Maryland's larger Heredity and Phenotype Intervention Study that examined how genes and lifestyle factors influence the risk of developing cardiovascular disease, was funded by the National Heart, Lung, and Blood Institute.

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Copyright Health Magazine 2009

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